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KMID : 0942820020010010007
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Journal of Korean Brain Tumor Society
2002 Volume.1 No. 1 p.7 ~ p.15
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Brain Tumor and Apoptosis
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Kim Myung-Sunny
Kim Tae-Young
Park Rae-Gil
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Abstract
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Apoptosis is a complex process that removes aging or damaged cells from the body and occurs in a wide variety of organisms. Malignant gliomas are well known for their intrinsic heterogeneity that contributes to tumour recurrence, regardless current aggressive multimodality of therapy. New approaches of non-surgical intervention are formulated, according to specific characteristics of glioma biology including angiogenesis, invasion, DNA-repair mechanisms, cell cycle regulation and apoptosis. Specific proapoptotic approaches may overcome many of the obvious obstacles to achieve a satisfactory management of brain tumors. Various therapeutic approaches toward successful eradication of glioma by an induction of apoptosis have been developed, however these approaches may be hampered frequently by anti-apoptotic mechanism. One promising experimental strategy in treatment of glioma is to activate apoptosis pathway within tumor cells, which will employ the death ligands such as CD95(Fas/Apo1) ligand or Apo2 ligand(TRAIL), cytosolic protease, growth factor-related signal molecules, and intracelluar organelles(mitochondria and golgi complex), etc. In this review, we described the representative apoptotic pathways including Bcl-2, caspase, death receptor, and tumor suppressor gene to suggest their possibilities of adaption in comprehensive treatment to overcome chemoresistance or radioresistance of human brain tumor cells.
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KEYWORD
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Apoptosis, Brain tumor, Death ligands, Chemoresistance
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